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Zofran Ondansetron tablets What do ondansetron tablets do?ONDANSETRON (Zofran(R), Zofran ODT(R)) helps to relieve nausea and vomiting, especially when associated with the treatment of cancer (chemotherapy). Ondansetron may also be used to prevent or treat nausea and vomiting that occurs after surgery, and occasionally is used to treat severe vomiting during pregnancy.