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Zaart H Hydrochlorothiazide, HCTZ; Losartan tablets What do losartan-hydrochlorothiazide tablets do?LOSARTAN-HYDROCHLOROTHIAZIDE (Hyzaar(R)) is a combination of two drugs used to lower blood pressure. Losartan controls high blood pressure (hypertension) by relaxing blood vessels. Hydrochlorothiazide is a diuretic. High blood pressure can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. By lowering blood pressure, losartan-hydrochlorothiazide can help reduce your risk of having damage to your kidneys, heart, or other organs. This medicine does not cure high blood pressure.