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Lisinopril Lisinopril tablets What do lisinopril tablets do?LISINOPRIL (Prinivil(R), Zestril(R)) is an antihypertensive (blood pressure lowering agent) known as an ACE inhibitor. Lisinopril controls high blood pressure (hypertension) by relaxing blood vessels; it is not a cure. High blood pressure levels can damage your kidneys, and may lead to a stroke or heart failure. Lisinopril also helps to treat patients with heart failure (heart does not pump strongly enough).