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Imuran Azathioprine tablets What do azathioprine tablets do?AZATHIOPRINE (Imuran(R)) is an immunosuppressive agent. It can suppress or reduce the body’s natural immunity, making it less able to fight infections and preventing the rejection of “foreign bodies”. Azathioprine reduces unwanted immune responses and helps to prevent rejection in patients who receive organ transplants. The response of the immune system may contribute to arthritis, and azathioprine helps to treat severe rheumatoid arthritis.