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Efudex Fluorouracil, 5-FU skin cream or solution What does fluorouracil skin cream or solution do?FLUOROURACIL, 5-FU (Carac(TM), Efudex(R), Fluoroplex(R)) is a topical chemotherapy agent used for treating certain skin problems, including skin cancer and skin conditions that could become cancer. Fluorouracil interferes with the growth of abnormal cells, which are eventually destroyed.