Arava Leflunomide tablets What do leflunomide tablets do?LEFLUNOMIDE is a medication that reduces inflammation and swelling due to rheumatoid arthritis. The response of the immune system may contribute to rheumatoid arthritis. Leflunomide affects this system and is able to slow down the progression of the disease, especially in the affected joints. Leflunomide helps to treat all stages of adult rheumatoid arthritis. Leflunomide can be used with some of the other medications that are used to treat the inflammation and pain of this condition (for example, aspirin, other salicylates, or nonsteroidal antiinflammatory drugs like ibuprofen).