Cyclosporine Cyclosporine capsules What do cyclosporine capsules do?CYCLOSPORINE (Sandimmune(R), Neoral(R), Gengraf(TM)) is a medication used to decrease the immune system’s response to a transplanted organ, which the body would otherwise see as foreign. Cyclosporine is used to reduce immune responses and prevent rejection in patients who receive organ or bone marrow transplants. Cyclosporine is also used to treat severe rheumatoid arthritis, psoriasis, Crohn’s disease or ulcerative colitis. Make sure you always use the same brand of cyclosporine unless your prescriber tells you to switch brands. Generic cyclosporine capsules are available.