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Paroxetine Paroxetine tablets or capsules, plain or extended-release What do paroxetine tablets or capsules, plain or extended-release do?PAROXETINE (Paxil(R), Paxil(R) CR(TM)) is classified as an antidepressant. It helps to improve a person’s mood by treating depression. Paroxetine can also help people with obsessive compulsive disorder or panic attacks. Paroxetine may also be prescribed for other purposes, like premenstrual syndrome.