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Zithromax Azithromycin tablets What do azithromycin tablets do?AZITHROMYCIN (Zithromax(R)) is a macrolide antibiotic that interferes with the growth of bacterial cells. It is used to treat bacterial infections in many different parts of the body. Azithromycin also treats sexually transmitted vaginal or urinary tract infections caused by chlamydia. It will not work for colds, flu, or other virus infections.