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Zyban Bupropion sustained-release tablets What do bupropion sustained-release tablets do?BUPROPION (Zyban(R)) is a prescription medicine to help people quit smoking. Bupropion can reduce the symptoms caused by stopping smoking. Bupropion can also decrease the urge to smoke and decrease nicotine cravings. Bupropion is used with a patient support program recommended by your physician. P>